Yakasimbiswa Procaine Benzylpenicillin Yokubaya

Chinyorwa:
Eeach vial rine:
Procaine penicillin bp ……………………… 3,000,000 iu
Benzylpenicillin sodium bp ………………… 1,000,000 iu

Tsanangudzo:
Ichena kana yakabviswa-chena isina tsvina poda.
Pharmacological chiito
Penicillin mushonga wechipfuva-wakasvinwa unorwisa mabhakitiriya unoshanda zvakanyanya pane zvakasiyana-siyana zvega gramu-hutachiona uye zvishoma gramu-isina cocci. mabhakitiriya anonyanya kubata ndeaya staphylococcus, streptococcus, mycobacterium tuberculosis, corynebacterium, clostridium tetanus, actinomycetes, bacillus anthracis, spirochetes, nezvimwe. pharmacokinetics mushure mekupinda mukati mejekiseni wepenicillin, inodhonzwa zvishoma nezvishoma mushure mekusunungura penicillin neiyo hydrolysis yemunharaunda. iyo nguva yepamusoro yakareba, kuiswa kweropa kwakaderera, asi mhedzisiro yacho yakareba kune penicillin. inogumira kune hutachiona hunonyanya kubata penicillin uye haufanire kushandiswa kurapa hutachiona hwakakomba. mushure mekunge procaine penicillin uye penicillin sodium (potasium) wakasanganiswa jekiseni, kusangana kweropa kunogona kuwedzera munguva pfupi, kupa zvese kuita kwenguva refu uye nekukurumidza kuita chiitiko. huwandu hwakawanda hwejekiseni hweproaini penicillin inogona kukonzera chepfu.

Pharmacodynamics penicillin ibhakitiriya inorwisa mabhakitiriya ine yakasimba antibacterial chiitiko. antibacterial maitiro ayo ndeyekuvhiringidza maitiro ehutachiona cell cell peptidoglycan. iwo mabhakitiriya anonzwa ari muchikamu chekukura akapatsanurwa nesimba, uye madziro echitokisi ari muchikamu chebiosynthesis. pasi pekuita kwepenicillin, iwo maitiro epeptidoglycan akavharika uye rusero rwemasokisi harugone kuumbwa, uye membrane yesero yakaputswa uye ikafa pasi pechiitiko cheasmotic kudzvanywa.

Penicillin mushonga wechipfuva-wakasvinwa unorwisa mabhakitiriya unoshanda zvakanyanya pane zvakasiyana-siyana zvega gramu-hutachiona uye zvishoma gramu-isina cocci. mabhakitiriya anonyanya kubata ndeaya staphylococcus, streptococcus, mycobacterium tuberculosis, corynebacterium, clostridium tetanus, actinomycetes, bacillus anthracis, spirochetes, nezvimwe.
pharmacokinetics mushure mekupinda mukati mejekiseni wepenicillin, inodhonzwa zvishoma nezvishoma mushure mekusunungura penicillin neiyo hydrolysis yemunharaunda. iyo nguva yepamusoro yakareba, kuiswa kweropa kwakaderera, asi mhedzisiro yacho yakareba kune penicillin. inogumira kune hutachiona hunonyanya kubata penicillin uye haufanire kushandiswa kurapa hutachiona hwakakomba. mushure mekunge procaine penicillin uye penicillin sodium (potasium) wakasanganiswa jekiseni, kusangana kweropa kunogona kuwedzera munguva pfupi, kupa zvese kuita kwenguva refu uye nekukurumidza kuita chiitiko. huwandu hwakawanda hwejekiseni hweproaini penicillin inogona kukonzera chepfu.

Kupindirana kwezvinodhaka
1. Penicillin yakasanganiswa neaminoglycosides inogona kuwedzera kushushikana kweyekupedzisira mubhakitiriya, saka ine synergistic mhedzisiro. 
2. Kukurumidza-kuita mabhakitiriya anoshanda sema macrolides, tetracyclines uye amide alcohols zvine zvinovhiringidza pakuita kwe bactericidal ye penicillin uye haifanirwe kushandiswa pamwe chete. 
3. Yakakura simbi ion (kunyanya ndarira, zinc, zebus), alcohols, asidhi, iodine, oxidants, kudzikisa vamiririri, hydroxy complements, acidic glucose jekiseni kana tetracycline hydrochloride jekiseni rinogona kuparadza basa repenicillin, zvinova zvinopesana. 
4. Amini nemapenicillin anogona kuumba isina kunyorova munyu, iwo unoshandura kutora. kudyidzana uku kunogona kunonoka kupinza penicillin, senge procaine penicillin. 
5. Uye zvimwe zvinodhaka zvinogadziriswa (senge chlorpromazine hydrochloride, lincomycin hydrochloride, norepinephrine tartrate, oxytetracycline hydrochloride, tetracycline hydrochloride, b mavitamin uye vhitamini c) haifanirwe kuve yakasanganiswa, zvikasadaro inogona kuburitsa turbidity, floc kana kuwanda.

Zviratidzo
Inonyanya kushandiswa kutapukira kusingaperi inokonzerwa ne penicillin-bhakitiriya inonzwa, senge pus muchibereko chemombe, mastitis, mapundu echipfu, nezvimwewo.
kushandiswa uye dosage
For intramuscular jekiseni. 
Dhigiri rimwe chete, pakirogiramu yehuremu hwemuviri, zviuru gumi kusvika makumi maviri ezviuru zvebhiza nemombe; Makumi maviri kusvika makumi matatu ezviuru zviuru zvemakwai, nguruve, mbongoro nemhuru; Makumi matatu kusvika makumi mana ezviuru embwa nembwa. kamwe pazuva, kwemazuva 2-3. 
wedzera yakakodzera mvura isina kudzivirira jekiseni kuti uite unomisa usati washandiswa.

Regency Reaction
1. Mhedzisiro huru yekusangana ndeye kusanzwisisika maitiro, ayo anogona kuitika mune mazhinji zvipfuyo, asi zviitiko zvakaderera. maitiro emuno anoonekwa ne edema uye kurwadziwa panzvimbo jekiseni, uye systemic reaction ndeye urticaria uye kupenga. mune zvakanyanya zviitiko, zvinogona kukonzera kuvhunduka kana kufa. 
2. Kune dzimwe mhuka, inogona kukonzera hutachiona hweviri hwegumbo remukati.

Mafambiro
1. Ichi chigadzirwa chinoshandiswa chete kurapa chirwere chisingaperi chinokonzerwa nehutachiona hwakanyanya.
2. Yakareruka inogadziriswa mumvura. kana uchisangana ne acid, alkali kana oxidant, inokurumidza kurasikirwa nekuita. saka, iyo jekiseni inofanira kugadzirira isati yashandiswa.
3. Teerera kutarisa kwekudyidzana uye kusawirirana nemamwe madhiragi, kuti arege kukanganisa kushanda kwayo.
kubvisa nguva
Mhou, gwai, uye nguruve: 28days; 
Kwemukaka: maawa makumi manomwe neshanu.

Kuchengetedza:
Kuiswa chisimbiso uye kuchengetwa munzvimbo yakaoma.